at Fairfield University
PUBLICATIONS
undergraduate researcher mentee *equal author contribution
17
Millar, D. C.; Marchand, J.; Roberts-Mataric, H.; Chen, T.; Hu, C.; Fang, J.; Millar, S.; Stone, E. A.; Pelton, J. G.; Sosa, M. B.; Chang, M. C. Y. tRNA-Deacylase Directed Discovery of Biosynthetic Pathways. ChemRxiv. 2025, DOI: 10.26434/chemrxiv-2025-p11hb.
16
Kissman, E. N.; Kipouros, I.; Slater, J. W.; Stone, E. A.; Yang, A. Y.; Braun, A.; Ensberg, A.; Whitten, A. M.; Chatterjee, K.; Bogacz, I.; Yano, J.; Bollinger, J. M.; Chang, M. C. Y. Dynamic Metal Coordination Controls Chemoselectivity in Radical Halogenases. BioRxiv. 2024, DOI: 10.1101/2024.09.19.613983.
15
Stone, E. A.; Whitten, A. M.; Angelisanti, N. M.; Kissman, E. N.; Millar, D. C.; Vargas-Figueroa, A.; Chang, M. C. Y. Discovery and Applications of a Lysine 5-Hydroxylase for Bioorthogonal Chemistry. ChemRxiv. 2024, DOI:10.26434/chemrxiv-2024-xj5bw.
14
Huth, S. E.; Stone, E. A.; Crotti, S.; Mercado, B. Q.; Miller, S. J. On the Ability of the N–O Bond to Support a Stable Stereogenic Axis: Peptide-Catalyzed Atroposelective N-Oxidation. J. Org. Chem. 2023, 88, 12857–12862.
13
Zhang, C.-H.; Spasov, K. A.; Reilly, R. A.; Hollander, K.; Stone, E. A.; Ippolito, J. A.; Liosi, M. -E.; Deshmukh, M. G.; Tirado-Rives, J.; Zhang, S.; Liang, Z.; Miller, S. J; Isaacs, F.; Lindenbach, B. D.; Anderson, K. S.; Jorgensen, W. L. Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency. ACS Med. Chem. Lett. 2021, 12, 1325–1332.
12
Deshmukh, M. G.; Ippolito, J. A.; Zhang, C.-H.; Stone, E. A.; Reilly, R. A.; Miller, S. J; Jorgensen, W. L.; Anderson, K. S. Structure-Guided Design of a Perampanel-Derived Pharmacophore Targeting the SARSCoV-2 Main Protease. Structure 2021, 29, 823–833.
11
Stone, E. A.*; Hosseinzadeh, P.*; Craven, T. W.; Robertson, M. J.; Han, Y.; Hsieh, S.-Y.; Metrano, A. J.; Baker, D.; Miller, S. J. Isolating Conformers to Assess Dynamics of Peptidic Catalysts Using Computationally Designed Macrocyclic Peptides. ACS Catal. 2021, 11, 4395–4400.
10
Zhang, C.-H.*; Stone, E. A.*; Deshmukh, M.*; Ippolito, J. A.*; Ghahremanpour, M. M.; Tirado-Rives, J.; Spasov, K. A.; Zhang, S.; Takeo, Y.; Kudalkar, S. N.; Liang, Z.; Isaacs, F.; Lindenbach, B.; Miller, S. J.; Anderson, K. A.; Jorgensen, W. L. Potent Non-Covalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free-Energy Perturbation Calculations. ACS Cent. Sci. 2021, 7, 467–475.
9
Metrano, A. J.; Chinn, A. J.; Shugrue, C. R.; Stone, E. A.; Kim, B.; Miller, S. J. Asymmetric Catalysis Mediated by Synthetic Peptides, Version 2.0: Expansion of Scope and Mechanisms. Chem. Rev. 2020, 120, 11479–11615.
8
DeLomba, W. C.; Stone, E. A.; Alley, K. A.; Iannarone, V.; Tarsis, E.; Ovaska, S.; Ovaska, T. V. Utilization of the Thorpe–Ingold Effect in the Synthesis of Cyclooctanoid Ring Systems via Anionic 6-exo-dig Cyclization/Claisen Rearrangement Sequence. J. Org. Chem. 2020, 85, 9464–9474.
7
Stone, E. A.; Cutrona, K. J.; Miller, S. J. Asymmetric Catalysis upon Helically Chiral Loratadine Analogues Unveils Enantiomer-Dependent Antihistamine Activity. J. Am. Chem. Soc. 2020, 142, 12690–12698.
6
Hsieh, S.-Y.; Tang, Y.; Crotti, S.; Stone, E. A.; Miller, S. J. Catalytic Enantioselective Pyridine N–Oxidation. J. Am. Chem. Soc. 2019, 141, 18624–18629.
5
Neu, J.; Stone, E. A.; Spies, J. A.; Storch, G.; Hatano, A. S.; Mercado, B. Q.; Miller, S. J.; Schmuttenmaer, C. A. Terahertz Spectroscopy of Tetrameric Peptides. J. Phys. Chem. Lett. 2019, 10, 2624–2628.
4
Hirsch, D. R.; Metrano, A. J.; Stone, E. A.; Storch, G.; Miller, S. J.; Murelli, R. P. Troponoid Atropisomerism: Studies on the Configurational Stability of Tropone-Amide Chiral Axes. Org. Lett. 2019, 21, 2412–2415.
3
Stone, E. A.; Mercado, B. Q.; Miller, S. J. Structure and Reactivity of Highly Twisted N-Acylimidazoles. Org. Lett. 2019, 21, 2346–2351.
2
Crawford, J. M.*; Stone, E. A.*; Metrano, A. J.; Miller, S. J.; Sigman, M. S. Parameterization and Analysis of Peptide-Based Catalysts for the Atroposelective Bromination of Arylquinazolin-4(3H)-ones. J. Am. Chem. Soc. 2018, 140, 868–871.
1
Hurtley, A. E.; Stone, E. A.; Metrano, A.J.; Miller, S. J. Desymmetrization of Diarylmethylamido Bis(phenols) through Peptide-Catalyzed Bromination: Enantiodivergence as a Consequence of a 2 amu Alteration at an Achiral Residue within the Catalyst. J. Org. Chem. 2017, 82, 11326–11336.
